Microwave assisted extraction of betulin from birch outer bark

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A preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (Betulae alba cortex).

During the last two decades triterpenes have attracted attention because of their pharmacological potential. Triterpene extract (TE) from outer bark of birch consisting mainly of betulin is able to form an oleogel which was successfully tested in the treatment of actinic keratosis. Some aspects of TE in vitro pharmacology are already known. Now we show preliminary pharmacokinetics of betulin an...

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Optimization of Microwave Assisted Alkaline Extraction of Xylan from Birch Wood Using Response Surface Methodology

The main purpose of this study was to optimize microwave assisted alkaline extraction of the hemicellulose, xylan, from birch wood. The simultaneous effects of process variables such as time (10 30 minutes), concentration of sodium hydroxide solution (4 8 wt%), solid to liquid ratio (1:8 to 1:20, g:mL), and sample size (5 10 g) on the temperature of the wood slurry, wood dissolution, and yield ...

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Application of Ionic Liquids in the Microwave-Assisted Extraction of Proanthocyanidins from Larix gmelini Bark

Ionic liquid based, microwave-assisted extraction (ILMAE) was successfully applied to the extraction of proanthocyanidins from Larix gmelini bark. In this work, in order to evaluate the performance of ionic liquids in the microwave-assisted extraction process, a series of 1-alkyl-3-methylimidazolium ionic liquids with different cations and anions were evaluated for extraction yield, and 1-butyl...

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Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation

UNLABELLED BACKGROUND Pentacyclic triterpenes, mainly betulin and betulinic acid, are valuable anticancer agents found in the bark of birch tree. This study evaluates birch bark extracts for the active principles composition. RESULTS New improved extraction methods were applied on the bark of Betula pendula in order to reach the maximum content in active principles. Extracts were analyzed ...

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Betulinic Acid from Zizyphus Joazeiro Bark Using Focused Microwave-Assisted Extraction and Response Surface Methodology

BACKGROUND The effect of the extraction time (min) and temperature (°C) on the yield of betulinic acid (BA) from Zizyphus joazeiro barks using focused microwave-assisted extraction was investigated. MATERIALS AND METHODS The ethyl acetate was used as extractor solvent because it was shown to provide a betulinic acid-clean extract. A full two-level statistical factorial design was applied to d...

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ژورنال

عنوان ژورنال: RSC Advances

سال: 2013

ISSN: 2046-2069

DOI: 10.1039/c3ra43868f